The effect of Mahogany seeds extract (Swietenia mahagoni) on the quantity of macrophages in the Post-tooth extraction wound healing phase of Wistar Rats (Rattus norvegicus)

Tooth extraction often cause tissue damage and wound. After tooth extraction, the wound healing process becomes a major concern because of many complications makes patients feel pain suffered. Lande et al. (2015) showed prevalence complications, including crown fracture (31.82%), root (13.6%), dry socket (4%), swelling (2.27%), bleeding (1.6%). Macrophages are common inflammatory cell in wounds, local macrophage population shifts from pro-inflammatory (M1-like phenotypes) to anti-inflammatory (M2-like phenotypes), indicating start next phase. Various alternative materials can help one which is mahogany seeds. Flavonoids found Mahagony seeds influence function by boosting synthesis PDGF, VEGF, cytokines, activating monocytes, raising number macrophages involved healing. Proving seed extract (Swietenia mahagoni) affects after extracting Wistar rat (Rattus norvegicus) teeth. 20 rats were divided into four groups there control group (K) performed without any treatment, three treatment (P1, P2, P3) topically induced with different doses (50 mg/200g rbw, 100mg/200g 200mg/200g rbw) post-extraction socket. sacrificed on 3rd day. Observations made reading histologic preparations using Hematoksilin Eosin (HE) 400x light microscope magnification. The quantity each differed significantly between 4 (p = 0.003), namely K1 P1 0.008), P3 0.001), P2 0.006). Mahogany process, 50mg/200g rbw as optimal dose